Kemerovo, Россия
Kemerovo, Кемеровская область, Россия
Kemerovo, Кемеровская область, Россия
Kemerovo, Кемеровская область, Россия
Kemerovo, Кемеровская область, Россия
Кемерово, Кемеровская область, Россия
ВАК 4.3.5 Биотехнология продуктов питания и биологически активных веществ
УДК 57 Биологические науки
Diseases associated with metabolic disorders seem to affect more and more people worldwide. Biologically active supplements may prevent or relieve metabolic disorders. Quercetin is known for its potential to inhibit metabolic syndrome. This paper introduces an in vivo experiment on rodents. It featured hypoglycemic, hypocholesterolemic, and hepatotoxic properties of quercetin. Quercetin was obtained from the hairy root extract of Hedysarum neglectum Ledeb. Two doses (50 and 100 mg/kg) were used to evaluate its hypoglycemic potential. Rats with induced diabetes were tested for body weight, glucose, and cholesterol while mice with induced hypercholesterolemia were checked for blood cholesterol changes. Potential biochemical and pathological changes in the liver were also studied on rats. Quercetin treatment caused neither significant health problems nor death in the model animals. It had no effect on body weight, even in the animals with induced diabetes. In addition, quercetin did not increase glucose and cholesterol in the blood and triggered no pathological changes in the liver. Quercetin isolated from H. neglectum hairy root extract demonstrated no hepatotoxicity. Unfortunately, it showed no beneficial effect on cholesterol and glucose levels and had no efficacy against metabolic syndrome. Further research is needed to assess the effect of quercetin on other metabolic markers, e.g., genes associated with the metabolism of lipids, carbohydrates, etc.
Quercetin, in vivo, Hedysarum neglectum, metabolic syndrome, hepatotoxicity, hypercholesterolemic activity, hypoglycemic activity
1. Uchendu IK, Ikebunwa OA, Okpagu CB. Cardiorenal protective effects of extracts of bitter leaf (Vernonia amygdalina L.) in animal model of metabolic syndrome. Foods and Raw Materials. 2024;12(2):264–272. https://doi.org/10.21603/2308-4057-2024-2-607
2. Li H-Y, Zhou D-D, Gan R-Y, Huang S-Y, Zhao C-N, Shang A, et al. Effects and mechanisms of probiotics, prebiotics, synbiotics, and postbiotics on metabolic diseases targeting gut microbiota: A narrative review. Nutrients. 2021;13(9):3211. https://doi.org/10.3390/nu13093211
3. Hosseini A, Razavi BM, Banach M, Hosseinzadeh H. Quercetin and metabolic syndrome: A review. Phytotherapy Research. 2021;35(10):5352–5364. https://doi.org/10.1002/ptr.7144
4. Vesnina A, Prosekov A, Atuchin V, Minina V, Ponasenko A. Tackling atherosclerosis via selected nutrition. International Journal of Molecular Sciences. 2022;23(15):8233. https://doi.org/10.3390/ijms23158233
5. Bilovol AN, Kniazkova II, Tverytinov AB, Korniichuk VI, Nesen AA, Zorenko NB. Therapeutic efficiency of quercetinum forin patiens with arterial hypertension and metabolic syndrome. West Kazakhstan Medical Journal. 2021;63(2):56–62. (In Russ.). https://doi.org/10.24412/2707-6180-2021-63-56-62; https://elibrary.ru/RESSVN
6. Reznik EV, Nikitin IG. Hypertension management in metabolic syndrome. Archive of Internal Medicine. 2019;9(5):327–347. (In Russ.). https://doi.org/10.20514/2226-6704-2019-9-5-327-347; https://elibrary.ru/MYBTFH
7. Bogdanova OG, Mylʹnikova IV. Metabolic syndrome: Situation in the world, clinical-diagnostic criteria and risk factors (review of literature). Hygiene and Sanitation. 2020;99(10):1165–1169. (In Russ.). https://doi.org/10.47470/0016-9900-2020-99-10-1165-1169; https://elibrary.ru/OJEAGH
8. Healthcare [Internet]. [cited 2024 Jan 15]. Available from: https://rosstat.gov.ru/folder/13721
9. Zhang K, Ma Y, Luo Y, Song Y, Xiong G, Ma Y, et al. Metabolic diseases and healthy aging: identifying environmental and behavioral risk factors and promoting public health. Frontiers in Public Health. 2023;11. https://doi.org/10.3389/fpubh.2023.1253506
10. Juárez-Fernández M, Porras D, García-Mediavilla MV, Román-Sagüillo S, González-Gallego J, Nistal E, et al. Aging, gut microbiota and metabolic diseases: Management through physical exercise and nutritional interventions. Nutrients. 2020;13(1):16. https://doi.org/10.3390/nu13010016
11. Baek SJ, Hammock BD, Hwang I-K, Li QX, Moustaid-Moussa N, Park Y, et al. Natural products in the prevention of metabolic diseases: Lessons learned from the 20th KAST frontier scientists workshop. Nutrients. 2021;13(6):1881. https://doi.org/10.3390/nu13061881
12. Dominguez LJ, Barbagallo M. The biology of the metabolic syndrome and aging. Current Opinion in Clinical Nutrition and Metabolic Care. 2016;19(1):5–11. https://doi.org/10.1097/MCO.0000000000000243
13. Babich O, Sukhikh S, Prosekov A, Asyakina L, Ivanova S. Medicinal plants to strengthen immunity during a pandemic. Pharmaceuticals. 2020;13(10):313. https://doi.org/10.3390/ph13100313
14. Milentyeva IS, Vesnina AD, Fedorova AM, Ostapova EV, Larichev TA. Chlorogenic acid and biohanin a from Trifolium pratense L. callus culture extract: Functional activity in vivo. Food Processing: Techniques and Technology. 2023;53(4):754–765. (In Russ.). https://doi.org/10.21603/2074-9414-2023-4-2475
15. Sotiropoulou M, Katsaros I, Vailas M, Lidoriki I, Papatheodoridis GV, Kostomitsopoulos NG, et al. Nonalcoholic fatty liver disease: The role of quercetin and its therapeutic implications. The Saudi Journal of Gastroenterology. 2021;27(6):319–330. https://doi.org/10.4103/sjg.sjg_249_21
16. Serba EM, Yuraskina TV, Rimareva LV, Tadzibova PYu, Sokolova EN, Volkova GS. Microbial biomass as a bioresource of functional food ingredients: A review. Food Processing: Techniques and Technology. 2023;53(3):426–444. (In Russ.). https://doi.org/10.21603/2074-9414-2023-3-2446
17. Shabbir U, Rubab M, Daliri EB-M, Chelliah R, Javed A, Oh D-H. Curcumin, quercetin, catechins and metabolic diseases: The role of gut microbiota. Nutrients. 2021;13(1):206. https://doi.org/10.3390/nu13010206
18. Xu X, Yi H, Wu J, Kuang T, Zhang J, Li Q, et al. Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence. Biomedicine and Pharmacotherapy. 2021;133:110984. https://doi.org/10.1016/j.biopha.2020.110984
19. Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, et al. Quercetin, inflammation and immunity. Nutrients. 2016;8(3):167. https://doi.org/10.3390/nu8030167
20. Faskhutdinova ER, Sukhikh AS, Le VM, Minina VI, Khelef MEA, Loseva AI. Effects of bioactive substances isolated from Siberian medicinal plants on the lifespan of Caenorhabditis elegans. Foods and Raw Materials. 2022;10(2):340–352. https://doi.org/10.21603/2308-4057-2022-2-544
21. Jasenovec T, Radosinska D, Kollarova M, Balis P, Ferenczyova K, Kalocayova B, et al. Beneficial effect of quercetin on erythrocyte properties in type 2 diabetic rats. Molecules. 2021;26(16):4868. https://doi.org/10.3390/molecules26164868
22. Gao X-R, Chen Z, Fang K, Xu J-X, Ge J-F. Protective effect of quercetin against the metabolic dysfunction of glucose and lipids and its associated learning and memory impairments in NAFLD rats. Lipids in Health and Disease. 2021;20:164. https://doi.org/10.1186/s12944-021-01590-x
23. Vesnina AD, Milentyeva IS, Dmitrieva AI, Prosekov AYu, Neverova OA. Prospects for the application of Hedysarum neglectum Ledeb as a cardioprotector. Agro-Industrial Complex of Russia. 2023;30(5):677–682. (In Russ.). https://doi.org/10.55934/10.55934/2587-8824-2023-30-5-677-682; https://elibrary.ru/OXZVNP
24. Vesnina A, Milentyeva I, Minina V, Kozlova O, Asyakina L. Evaluation of the in vivo anti-atherosclerotic activity of quercetin isolated from the hairy roots of Hedysarum neglectum Ledeb. Life. 2023;13(8):1706. https://doi.org/10.3390/life13081706
25. Prosekov AYu, Vesnina AD, Kozlova OV. The methodology of food design. Part 2. Digital nutritiology in personal food. Theory and Practice of Meat Processing. 2021;6(4):328–334. https://doi.org/10.21323/2414-438X-2021-6-4-328-334; https://elibrary.ru/KUFMRE
26. Ighodaro OM, Adeosun AM, Akinloye OA. Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies. Medicina. 2017;53(6):365–374. https://doi.org/10.1016/j.medici.2018.02.001
27. Rabbani SI, Devi K, Khanam S. Protective role of glibenclamide against nicotinamide-streptozotocin induced nuclear damage in diabetic Wistar rats. Journal of Pharmacology and Pharmacotherapeutics. 2010;1(1):18–23. https://doi.org/10.4103/0976-500X.64531
28. Muthian G, Bright JJ. Quercetin, a flavonoid phytoestrogen, ameliorates experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T lymphocyte. Journal of Clinical Immunology. 2004;24:542–552. https://doi.org/10.1023/B:JOCI.0000040925.55682.a5
29. Glushanko VS. Basic medical statistics. Vitebsk: VGMU; 2012. 155 p. (In Russ.).
30. Vessal M, Hemmati M, Vasei M. Antidiabetic effects of quercetin in streptozocin-induced diabetic rats. Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology. 2003;135(3):357–364. https://doi.org/10.1016/s1532-0456(03)00140-6
31. Kılıçarslan G, Dönmez N. The effects of quercetin on antioxidant system and some blood parameters in experimental diabetic rats. Bulletin of Environment, Pharmacology and Life Sciences. 2016;5(6):28–32.
32. Zhang R, Yao Y, Wang Y, Ren G. Antidiabetic activity of isoquercetin in diabetic KK -Ay mice. Nutrition and Metabolism. 2011;8:85. https://doi.org/10.1186/1743-7075-8-85
33. Bhaskar S, Kumar KS, Krishnan K, Antony H. Quercetin alleviates hypercholesterolemic diet induced inflammation during progression and regression of atherosclerosis in rabbits. Nutrition. 2013;29(1):219–229. https://doi.org/10.1016/j.nut.2012.01.019
34. Rivera L, Morón R, Sánchez M, Zarzuelo A, Galisteo M. Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obesity. 2008;16(9):2081–2087. https://doi.org/10.1038/oby.2008.315
35. Zhao L, Cen F, Tian F, Li M-J, Zhang Q, Shen H-Y, et al. Combination treatment with quercetin and resveratrol attenuates high fat diet-induced obesity and associated inflammation in rats via the AMPKα1/SIRT1 signaling pathway. Experimental and Therapeutic Medicine. 2017;14(6):5942–5948. https://doi.org/10.3892/etm.2017.5331
