MECHANISMS OF ESCAPE FROM REPLICATIVE SENESCENCE OF TUMOUR CELLS AFTER EXPOSURE TO CHEMOTHERAPY
Authors:
5.
Russian Federation
Type:
Сonference abstract
Published:
16.02.2023
Subject area:
UDK 57 Биологические науки
Language:
Russian
Keywords:
cellular aging, replicative aging, dedifferentiation, cisplatin
Abstract (English):
In 25% of patients with breast cancer, tumor cells after neoadjuvant chemotherapy (NAHT) leave the state of replicative aging and form macrometastases. In patients with breast cancer, it was shown that the exit from replicative aging with metastasis is observed only in those patients in whose tumor WNT signaling is ectopically activated due to amplification of activator genes and deletions of negative regulators of this signaling pathway. Purpose: in a direct experiment on cell cultures differing in ectopic activation of WNT signaling due to CNA (Copy Number Aberration) WNT signaling genes, to study the ability of tumor cells to exit replicative senescence after exposure to chemotherapy drugs.
In 25% of patients with breast cancer, tumor cells after neoadjuvant chemotherapy (NAHT) leave the state of replicative aging and form macrometastases. In patients with breast cancer, it was shown that the exit from replicative aging with metastasis is observed only in those patients in whose tumor WNT signaling is ectopically activated due to amplification of activator genes and deletions of negative regulators of this signaling pathway. Purpose: in a direct experiment on cell cultures differing in ectopic activation of WNT signaling due to CNA (Copy Number Aberration) WNT signaling genes, to study the ability of tumor cells to exit replicative senescence after exposure to chemotherapy drugs.
Keywords:
cellular aging, replicative aging, dedifferentiation, cisplatin
cellular aging, replicative aging, dedifferentiation, cisplatin
1. Amplifications of stemness genes and the capacity of breast tumors for metastasis // Oncotarget. 2020. 11. pp.1988-2001
