Kemerovo, Kemerovo, Russian Federation
Kemerovo, Kemerovo, Russian Federation
Kemerovo, Russian Federation
The purpose of this work is to study the biocompatibility of probiotic strains Lactobacillus plantarum B-1615, Lactobacillus brevis B-2429, Bacillus subtilis B-7918, Enterococcus faecium B5000 and Lactobacillus paracasei B-2430 to create a biologically active supplement. A drip technique was used to study biocompatibility. It was found that biocompatibility is possessed by combinations of strains Lactobacillus plantarum B-1615 and Lactobacillus brevis B-2429; Lactobacillus plantarum B1615 and Bacillus subtilis 21 B-7918; Lactobacillus plantarum B-1615 and Lactobacillus paracasei B2430; Lactobacillus brevis B-2429 and Enterococcus faecium B -5000; Lactobacillus brevis B-2429 and Lactobacillus paracasei B-2430; Bacillus subtilis 21 B-7918 and Enterococcus faecium B-5000.
gastrointestinal tract, bacteriocins, biologically active additive, probiotic microorganisms, biocompatibility
1. Gut microbiota as a source of novel antimicrobials / E. Garcia-Gutierrez, M. J. Mayer, P. D. Cotter et al. // Gut microbes. 2019. Vol. 10. No 1. P. 1-21.
2. Effects of metabolites derived from gut microbiota and hosts on pathogens / Z. Li, G. Quan, X. Jiang, Y. Yang, et al. // Frontiers in cellular and infection microbiology. 2018. P. 314.
3. Functions and emerging applications of bacteriocins / M. L. Chikindas, R. Weeks, D. Drider et al. // Current opinion in biotechnology. 2018. Vol. 49. P. 23-28.
4. Prospects for Using Bacteriocins of Normal Microbiota in Antibacterial Therapy (Review) / M. I. Zaslavskaya, T. V. Makhrova, N. A. Aleksandrova et al. // Modern Technologies in Medicine. 2019. Vol. 11. No 3. P. 136-145.
5. Overview of global trends in classification, methods of preparation and application of bacteriocins / M.Zimina, O. Babich, A. Prosekov, et al. // Antibiotics. 2020. Vol. 9, No. 9. P. 553
6. Volkova, G.S. Investigation of biological interstrains and growing properties of lactic acid bacteria production strains / G. S. Volkova, E. V. Kuksova, E. M. Serba // Topical issues of the dairy industry, intersectoral technologies and quality management systems. 2020. Vol. 1, No 1(1). P. 104-109.
