<!DOCTYPE article
PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20190208//EN"
       "JATS-journalpublishing1.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.4" xml:lang="en">
 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Food Processing: Techniques and Technology</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Food Processing: Techniques and Technology</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Техника и технология пищевых производств</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2074-9414</issn>
   <issn publication-format="online">2313-1748</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">100135</article-id>
   <article-id pub-id-type="doi">10.21603/2074-9414-2025-2-2571</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>ОРИГИНАЛЬНАЯ СТАТЬЯ</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>ORIGINAL ARTICLE</subject>
    </subj-group>
    <subj-group>
     <subject>ОРИГИНАЛЬНАЯ СТАТЬЯ</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">Fortified Protein Concentrate Based on Milk Whey</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Получение обогащенного белкового концентрата на основе молочной сыворотки</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5664-6028</contrib-id>
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Лебедева</surname>
       <given-names>Светлана Николаевна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Lebedeva</surname>
       <given-names>Svetlana N.</given-names>
      </name>
     </name-alternatives>
     <email>lebedeva1959@mail.ru</email>
     <bio xml:lang="ru">
      <p>доктор биологических наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>doctor of sciences in biology;</p>
     </bio>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Щёкотова</surname>
       <given-names>Анна Владимировна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Shchekotova</surname>
       <given-names>Anna V.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
    <contrib contrib-type="author">
     <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8488-8427</contrib-id>
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Атласова</surname>
       <given-names>Дарья Владимировна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Atlasova</surname>
       <given-names>Daria V.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-3"/>
    </contrib>
    <contrib contrib-type="author">
     <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4294-5857</contrib-id>
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Хамагаева</surname>
       <given-names>Ирина Сергеевна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Khamagaeva</surname>
       <given-names>Irina S.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-4"/>
    </contrib>
    <contrib contrib-type="author">
     <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2644-0779</contrib-id>
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Котова</surname>
       <given-names>Татьяна Ивановна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Kotova</surname>
       <given-names>Tatiana I.</given-names>
      </name>
     </name-alternatives>
     <bio xml:lang="ru">
      <p>кандидат технических наук;адъюнкт архитектуры;кандидат технических наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>candidate of technical sciences;adjunct of architecture;candidate of technical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-5"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">Восточно-Сибирский государственный университет технологий и управления</institution>
     <city>Улан-Удэ</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">East Siberia State University of Technology and Management</institution>
     <city>Ulan-Ude</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-2">
    <aff>
     <institution xml:lang="ru">Восточно-Сибирский государственный университет технологий и управления</institution>
     <city>Улан-Удэ</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">East Siberian State University of Technology and Management</institution>
     <city>Ulan-Ude</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-3">
    <aff>
     <institution xml:lang="ru">Дальневосточный федеральный университет</institution>
     <city>Владивосток</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Far Eastern Federal University</institution>
     <city>Vladivostok</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-4">
    <aff>
     <institution xml:lang="ru">Восточно-Сибирский государственный университет технологий и управления</institution>
     <city>Улан-Удэ</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">East Siberia State University of Technology and Management</institution>
     <city>Ulan-Ude</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-5">
    <aff>
     <institution xml:lang="ru">Восточно-Сибирский государственный университет технологий и управления</institution>
     <city>Улан-Удэ</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">East Siberian State University of Technology and Management</institution>
     <city>Ulan-Ude</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <pub-date publication-format="print" date-type="pub" iso-8601-date="2025-06-23T00:00:00+03:00">
    <day>23</day>
    <month>06</month>
    <year>2025</year>
   </pub-date>
   <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2025-06-23T00:00:00+03:00">
    <day>23</day>
    <month>06</month>
    <year>2025</year>
   </pub-date>
   <volume>55</volume>
   <issue>2</issue>
   <fpage>257</fpage>
   <lpage>271</lpage>
   <history>
    <date date-type="received" iso-8601-date="2024-07-16T00:00:00+03:00">
     <day>16</day>
     <month>07</month>
     <year>2024</year>
    </date>
    <date date-type="accepted" iso-8601-date="2025-04-01T00:00:00+03:00">
     <day>01</day>
     <month>04</month>
     <year>2025</year>
    </date>
   </history>
   <self-uri xlink:href="https://fptt.ru/en/issues/23587/23597/">https://fptt.ru/en/issues/23587/23597/</self-uri>
   <abstract xml:lang="ru">
    <p>Вопрос утилизации / переработки молочной сыворотки является актуальной проблемой молочных предприятий. Нерентабельность используемых методов и отсутствие энергосберегающих промышленных технологий замедляет решение данной проблемы. Молочная сыворотка – ценное сырье, содержащее более 200 органических и минеральных компонентов, из которого можно получать продукты, обладающие полезными биологическими свойствами. Цель работы – получить из творожной сыворотки обогащенный белковый продукт с использованием магниевой термокоагуляции белков и дальнейшей ферментации комплексной лактобактериальной закваской.&#13;
Объектом исследования послужила творожная сыворотка, полученная методом кислотно-сычужной коагуляции в процессе производства творога с массовой долей жира 9 %. Температура была доведена до +35–40 °С посредством водяной бани с последующим удалением жира и казеиновой пыли на сепараторе-сливкоотделителе. Осветление молочной сыворотки с получением пермеата проводили тепловой денатурацией при 92 ± 1 °С с добавлением 10 % раствора MgCl2×6H2O в концентрациях 2–42 г/л. Белок подвергли вакуумной фильтрации. Ферментация сывороточных белков осуществлялась комплексной закваской из четырех штаммов Lactobacillus. В исследовании использовались стандартные, общепринятые физико-химические и микробиологические методы.&#13;
В результате установлен оптимальный режим термомагниевой денатурации молочной сыворотки (92 ± 1 °С в течение 5–10 мин и MgCl2 в количестве 18 г/л), способствующий максимальному выходу белка (25,0 г/л) и содержанию магния (2,4 мг/г). Ферментация магниевого концентрата термически осажденных белков молочной сыворотки закваской приводила к активизации процесса протеолиза, формированию необходимых физико-химических и органолептических свойств. В результате сублимационной сушки –40 °С в течение 18–20 ч был получен сухой продукт с достаточным количеством живых клеток лактобактерий (1–3×107) и содержанием магния 907 мг/100 г.&#13;
Разработанная технология позволила получить из молочной сыворотки магнийсодержащий концентрат термически осажденных белков с высокой биологической ценностью. Качественные показатели концентрата обеспечивают широкий спектр возможностей для применения в различных сферах пищевой индустрии.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>Utilization and processing of milk whey have become a pressing problem for the dairy industry as a result of unprofitable production methods and the poor energy-saving industrial technologies. Milk whey is a valuable raw material that contains more than 200 organic and mineral components. It can be processes into products with useful biological properties. The article describes a new fortified protein curd whey product obtained with magnesium thermal coagulation of proteins and fermented with a complex lactobacillus starter.&#13;
The curd whey was obtained by acid-rennet coagulation as a by-product of cottage cheese with a fat mass fraction of 9%. After +35–40°C in water bath, fat and casein powder were removed in a cream separator. The permeate was obtained by thermal denaturation at 92 ± 1°C with a 10% MgCl2×6H2O solution in concentrations of 2–42 g/L. The protein was then subjected to vacuum filtration. The fermentation of whey proteins involved a complex starter culture of four Lactobacillus strains. The research relied on standard physicochemical and microbiological methods.&#13;
The optimal mode for thermal magnesium denaturation of milk whey was 92 ± 1°C for 5–10 min with 18 g/L MgCl2. It yielded 25.0 g/L protein with 2.4 mg/g magnesium. When the magnesium concentrate of thermally precipitated whey proteins was fermented with the complex starter culture, it activated the proteolysis process, as well as provided the targeted physicochemical and sensory properties. After freeze-drying at –40°C for 18–20 h, the powder obtained was rich in living lactobacilli cells (1–3×107) and contained 907 mg/100 g magnesium.&#13;
The new method made it possible to turn whey wastes into a magnesium-containing concentrate of thermally precipitated proteins with increased biological value. Its qualitative indicators provide a wide range of possibilities in various areas of the food industry.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>Молочная сыворотка</kwd>
    <kwd>термомагниевая коагуляция</kwd>
    <kwd>белковый продукт</kwd>
    <kwd>Lactobacillus</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>Whey</kwd>
    <kwd>thermal magnesium coagulation</kwd>
    <kwd>protein product</kwd>
    <kwd>probiotic cultures</kwd>
    <kwd>Lactobacillus</kwd>
   </kwd-group>
   <funding-group>
    <funding-statement xml:lang="ru">Исследование выполнено за счет гранта Российского научного фонда № 24-26-20042, https://rscf.ru/ project/24-26-20042/</funding-statement>
    <funding-statement xml:lang="en">The research was supported by the Russian Science Foundation, grant no. 24-26-20042, https://rscf.ru/en/project/24-26-20042/</funding-statement>
   </funding-group>
  </article-meta>
 </front>
 <body>
  <p></p>
 </body>
 <back>
  <ref-list>
   <ref id="B1">
    <label>1.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Buchanan D, Martindale W, Romeih E, Hebishy E. Recent advances in whey processing and valorisation: Technological and environmental perspectives. International Journal of Dairy Technology. 2023;76(2):291–312. https://doi.org/10.1111/1471-0307.12935</mixed-citation>
     <mixed-citation xml:lang="en">Buchanan D, Martindale W, Romeih E, Hebishy E. Recent advances in whey processing and valorisation: Technological and environmental perspectives. International Journal of Dairy Technology. 2023;76(2):291–312. https://doi.org/10.1111/1471-0307.12935</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B2">
    <label>2.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Perez-Marroquín XA, Estrada-Fernández AG, García-Ceja A, Aguirre-Álvarez G, León-López A. Agro-food waste as an ingredient in functional beverage processing: Sources, functionality, market and regulation. Foods. 2023;12(8):1583. https://doi.org/10.3390/foods12081583</mixed-citation>
     <mixed-citation xml:lang="en">Perez-Marroquín XA, Estrada-Fernández AG, García-Ceja A, Aguirre-Álvarez G, León-López A. Agro-food waste as an ingredient in functional beverage processing: Sources, functionality, market and regulation. Foods. 2023;12(8):1583. https://doi.org/10.3390/foods12081583</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B3">
    <label>3.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Паладий И. В., Врабие Е. Г., Спринчан К. Г., Болога М. К. Молочная сыворотка: обзор работ. Часть 1. Классификация, состав, свойства, производные, применение. Электронная обработка материалов. 2021. Т. 57. № 1. С. 52–69. https://doi.org/10.5281/zenodo.4456698</mixed-citation>
     <mixed-citation xml:lang="en">Paladii IV, Vrabie EG, Sprincian CG, Bologa MK. Whey: The state of the Art. Part I. Classification, composition, properties, derivatives, applications. Electronic processing of raw materials. 2021;57(1):52–69. (In Russ.) https://doi.org/10.5281/zenodo.4456698</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B4">
    <label>4.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Мельникова Е. И., Богданова Е. В., Павельева Д. А. Мировой и российский рынок сывороточных ингредиентов. Молочная промышленность. 2020. № 8. С. 56–58. https://elibrary.ru/WZHSMF</mixed-citation>
     <mixed-citation xml:lang="en">Melnikova EI, Bogdanova EV, Paveleva DA. The world and Russian market of whey ingredients. Dairy Industry. 2020;(8):56–58. (In Russ.) https://elibrary.ru/WZHSMF</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B5">
    <label>5.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Кручинин А. Г., Шилова Е. Е. Исследование процесса баромембраной фильтрации подсырной и творожной сывороток. Актуальные вопросы молочной промышленности, межотраслевые технологии и системы управления качеством. 2020. Т. 1. № 1. С. 298–305. https://doi.org/10.37442/978-5-6043854-1-8-2020-1-298-305</mixed-citation>
     <mixed-citation xml:lang="en">Kruchinin AG, Shilova EE. The investigation of the process of cheese whey and quark whey barometric filtration. Current issues of the dairy industry, inter-industry technologies, and quality management systems. 2020;1(1):298–305. (In Russ.) https://doi.org/10.37442/978-5-6043854-1-8-2020-1-298-305</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B6">
    <label>6.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Soumati B, Atmani M, Benabderrahmane A, Benjelloun M. Whey valorization – Innovative strategies for sustainable development and value-added product creation. Journal of Ecological Engineering. 2023;24(10):86–104. https://doi.org/10.12911/22998993/169505</mixed-citation>
     <mixed-citation xml:lang="en">Soumati B, Atmani M, Benabderrahmane A, Benjelloun M. Whey valorization – Innovative strategies for sustainable development and value-added product creation. Journal of Ecological Engineering. 2023;24(10):86–104. https://doi.org/10.12911/22998993/169505</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B7">
    <label>7.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Guo M, Wang G. History of whey production and whey protein manufacturing. In: Guo M, editor. Whey Protein Production, Chemistry, Functionality, and Applications. Hoboken, NJ: John Wiley &amp; Sons, 2019, pp. 1–12. https://doi.org/10.1002/9781119256052.ch1</mixed-citation>
     <mixed-citation xml:lang="en">Guo M, Wang G. History of whey production and whey protein manufacturing. In: Guo M, editor. Whey Protein Production, Chemistry, Functionality, and Applications. Hoboken, NJ: John Wiley &amp; Sons, 2019, pp. 1–12. https://doi.org/10.1002/9781119256052.ch1</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B8">
    <label>8.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">El-Aidie SAM, Khalifa GSA. Innovative applications of whey protein for a sustainable dairy industry: environmental and technological perspectives – A comprehensive review. Comprehensive Reviews in Food Science and Food Safety. 2024;23(2):e13319. https://doi.org/10.1111/1541-4337.13319</mixed-citation>
     <mixed-citation xml:lang="en">El-Aidie SAM, Khalifa GSA. Innovative applications of whey protein for a sustainable dairy industry: Environmental and technological perspectives – a comprehensive review. Comprehensive Reviews in Food Science and Food Safety. 2024;23(2):e13319. https://doi.org/10.1111/1541-4337.13319</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B9">
    <label>9.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Chen GQ, Qu Y, Gras SL, Kentish SE. Separation technologies for whey protein fractionation. Food Engineering Reviews. 2023;15(3):438–465. https://doi.org/10.1007/s12393-022-09330-2</mixed-citation>
     <mixed-citation xml:lang="en">Chen GQ, Qu Y, Gras SL, Kentish SE. Separation technologies for whey protein fractionation. Food Engineering Reviews. 2023;15(3):438–465. https://doi.org/10.1007/s12393-022-09330-2</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B10">
    <label>10.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Smithers GW. Whey and whey proteins from ‘gutter-to-gold’. International Dairy Journal. 2008;18(7):695–704. https://doi.org/10.1016/j.idairyj.2008.03.008</mixed-citation>
     <mixed-citation xml:lang="en">Smithers GW. Whey and whey proteins from ‘gutter-to-gold’. International Dairy Journal. 2008;18(7):695–704. https://doi.org/10.1016/j.idairyj.2008.03.008</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B11">
    <label>11.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Smithers GW. Whey-ing up the options – Yesterday, today and tomorrow. International Dairy Journal. 2015;48:2–14. https://doi.org/10.1016/j.idairyj.2015.01.011</mixed-citation>
     <mixed-citation xml:lang="en">Smithers GW. Whey-ing up the options – Yesterday, today and tomorrow. International Dairy Journal. 2015;48:2–14. https://doi.org/10.1016/j.idairyj.2015.01.011</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B12">
    <label>12.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Ayed L, M'hir S, Asses N. Sustainable whey processing techniques: Innovations in derivative and beverage production. Food Bioscience. 2023;53:102642. https://doi.org/10.1016/j.fbio.2023.102642</mixed-citation>
     <mixed-citation xml:lang="en">Ayed L, M'hir S, Asses N. Sustainable whey processing techniques: Innovations in derivative and beverage production. Food Bioscience. 2023;53:102642. https://doi.org/10.1016/j.fbio.2023.102642</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B13">
    <label>13.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Молибога Е. А., Сухостав Е. В., Козлова О. А., Зинич А. В. Анализ рынка функционального питания: российский и международный аспект. Техника и технология пищевых производств. 2022. Т. 52. № 4. С. 775–786. https://doi.org/10.21603/2074-9414-2022-4-2405</mixed-citation>
     <mixed-citation xml:lang="en">Moliboga EA, Sukhostav EV, Kozlova OA, Zinich AV. Functional food market analysis: Russian and international aspects. Food Processing: Techniques and technology. 2022;52(4):775–786. (In Russ.) https://doi.org/10.21603/2074-9414-2022-4-2405</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B14">
    <label>14.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Minj S, Anand S. Whey proteins and its derivatives: Bioactivity, functionality and current applications. Dairy. 2020;1(3):233–258. https://doi.org/10.3390/dairy1030016</mixed-citation>
     <mixed-citation xml:lang="en">Minj S, Anand S. Whey proteins and its derivatives: Bioactivity, functionality and current applications. Dairy. 2020;1(3):233–258. https://doi.org/10.3390/dairy1030016</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B15">
    <label>15.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Мельникова Е. И., Станиславская Е. Б., Богданова Е. В., Шабалова Е. Д. Особенности получения и применения мицеллярного казеина в технологии молокоемких белковых продуктов. Техника и технология пищевых производств. 2022. Т. 52. № 3. С. 592–601. https://doi.org/10.21603/2074-9414-2022-3-2389</mixed-citation>
     <mixed-citation xml:lang="en">Melnikova EI, Stanislavskaya EB, Bogdanova EV, Shabalova ED. Micellar casein production and application in dairy protein industry. Food Processing: Techniques and Technology. 2022;52(3):592–601. (In Russ.) https://doi.org/10.21603/2074-9414-2022-3-2389</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B16">
    <label>16.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">O'Donoghue LT, Murphy EG. Nondairy food applications of whey and milk permeates: Direct and indirect uses. Comprehensive Reviews in Food Science and Food Safety. 2023;22(4):2652–2677. https://doi.org/10.1111/1541-4337.13157</mixed-citation>
     <mixed-citation xml:lang="en">O'Donoghue LT, Murphy EG. Nondairy food applications of whey and milk permeates: Direct and indirect uses. Comprehensive Reviews in Food Science and Food Safety. 2023;22(4):2652–2677. https://doi.org/10.1111/1541-4337.13157</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B17">
    <label>17.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Pillai AT, Morya S, Kasankala LM. Emerging trends in bioavailability and pharma-nutraceuticalpotential of whey bioactives. Journal of Nutrition and Metabolism. 2024;2024(1):8455666. https://doi.org/10.1155/2024/8455666</mixed-citation>
     <mixed-citation xml:lang="en">Pillai AT, Morya S, Kasankala LM. Emerging trends in bioavailability and pharma-nutraceuticalpotential of whey bioactives. Journal of Nutrition and Metabolism. 2024;2024(1):8455666. https://doi.org/10.1155/2024/8455666</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B18">
    <label>18.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Zhao С, Chen N, Ashaolu TJ. Whey proteins and peptides in health-promoting – A review. International Dairy Journal. 2022;126:105269. https://doi.org/10.1016/j.idairyj.2021.105269</mixed-citation>
     <mixed-citation xml:lang="en">Zhao C, Chen N, Ashaolu TJ. Whey proteins and peptides in health-promoting – A review. International Dairy Journal. 2022;126:105269. https://doi.org/10.1016/j.idairyj.2021.105269</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B19">
    <label>19.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Hameed A, Anwar MJ, Perveen S, Amir M, Naeem I, et al. Functional, industrial and therapeutic applications of dairy waste materials. International Journal of Food Properties. 2023;26(1):1470–1496. https://doi.org/10.1080/10942912.2023.2213854</mixed-citation>
     <mixed-citation xml:lang="en">Hameed A, Anwar MJ, Perveen S, Amir M, Naeem I, et al. Functional, industrial and therapeutic applications of dairy waste materials. International Journal of Food Properties. 2023;26(1):1470–1496. https://doi.org/10.1080/10942912.2023.2213854</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B20">
    <label>20.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Jakopović KL, Jurina IB, Božanić R. Trends in utilization of whey and buttermilk – Valuable by-products of the dairy industry. In: Spizzirri UG, editor. Nutraceutics from Agri-Food By-Products. Beverly, MA: Scrivener Publishing; 2023, pp. 245–283. https://doi.org/10.1002/9781394174867.ch8</mixed-citation>
     <mixed-citation xml:lang="en">Jakopović KL, Jurina IB, Božanić R. Trends in utilization of whey and buttermilk – Valuable by-products of the dairy industry. In: Spizzirri UG, editor. Nutraceutics from Agri-Food By-Products. Beverly, MA: Scrivener Publishing; 2023, pp. 245–283. https://doi.org/10.1002/9781394174867.ch8</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B21">
    <label>21.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Goyal C, Dhyani P, Rai DC, Tyagi S, Dhull SB, et al. Emerging trends and advancements in the processing of dairy whey for sustainable biorefining. Journal of Food Processing and Preservation. 2023;2023(1):6626513. https://doi.org/10.1155/2023/6626513</mixed-citation>
     <mixed-citation xml:lang="en">Goyal C, Dhyani P, Rai DC, Tyagi S, Dhull SB, et al. Emerging trends and advancements in the processing of dairy whey for sustainable biorefining. Journal of Food Processing and Preservation. 2023;2023(1):6626513. https://doi.org/10.1155/2023/6626513</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B22">
    <label>22.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Soumati B, Atmani M, Benabderrahmane A, Benjelloun M, et al. Whey valorization – Innovative strategies for sustainable development and value-added product creation. Journal of Ecological Engineering. 2023;24(10):86–104. https://doi.org/10.12911/22998993/169505</mixed-citation>
     <mixed-citation xml:lang="en">Soumati B, Atmani M, Benabderrahmane A, Benjelloun M, et al. Whey valorization – Innovative strategies for sustainable development and value-added product creation. Journal of Ecological Engineering. 2023;24(10):86–104. https://doi.org/10.12911/22998993/169505</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B23">
    <label>23.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Olvera-Rosales LB, Cruz-Guerrero AE, García-Garibay JM, Gómez-Ruíz LC, Contreras-López E, et al. Bioactive peptides of whey: obtaining, activity, mechanism of action, and further applications. Critical Reviews in Food Science and Nutrition. 2023;63(30):10351–10381. https://doi.org/10.1080/10408398.2022.2079113</mixed-citation>
     <mixed-citation xml:lang="en">Olvera-Rosales LB, Cruz-Guerrero AE, García-Garibay JM, Gómez-Ruíz LC, Contreras-López E, et al. Bioactive peptides of whey: Obtaining, activity, mechanism of action, and further applications. Critical Reviews in Food Science and Nutrition. 2023;63(30):10351–10381. https://doi.org/10.1080/10408398.2022.2079113</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B24">
    <label>24.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Паладий И. В., Врабие Е. Г., Спринчан К. Г., Болога М. К. Молочная сыворотка: обзор работ. Часть 2. Процессы и методы обработки. Электронная обработка материалов. 2021. Т. 57. № 3. С. 83–101. https://elibrary.ru/BEZPSE</mixed-citation>
     <mixed-citation xml:lang="en">Paladii IV, Vrabie EG, Sprincian CG, Bologa MK. Whey: The state of the Art. Part II. Processes and treatment methods. Electronic processing of raw materials. 2021;57(3):83–101. (In Russ.) https://elibrary.ru/BEZPSE</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B25">
    <label>25.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Chen GQ, Qu Y, Gras SL, Kentish SE. Separation technologies for whey protein fractionation. Food Engineering Reviews. 2023;15:438–465. https://doi.org/10.1007/s12393-022-09330-2</mixed-citation>
     <mixed-citation xml:lang="en">Chen GQ, Qu Y, Gras SL, Kentish SE. Separation technologies for whey protein fractionation. Food Engineering Reviews. 2023;15:438–465. https://doi.org/10.1007/s12393-022-09330-2</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B26">
    <label>26.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Лазарев В. А. Разделение и концентрирование молочной сыворотки на ультрафильтрационных и обратноосмотических мембранах: дисс. … канд. техн. наук: 05.17.18. Екатеринбург, 2015. 119 с. https://elibrary.ru/CLFTDG</mixed-citation>
     <mixed-citation xml:lang="en">Lazarev VA. Separation and concentration of whey using ultrafiltration and reverse osmosis membranes: Cand. Sci. Eng. Diss. Ekaterinburg, 2015. 119 p. (In Russ.) https://elibrary.ru/CLFTDG</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B27">
    <label>27.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Satya R, Singh A, Rasane P, Poonia A, Singh J, Kaur S, et al. Recent trends in membrane processing of whey. In: Poonia A, Petkoska AT, editors. Whey valorization: Innovations, technological advancements and sustainable exploitation. Singapore: Springer Nature; 2023. pp. 323–353. https://doi.org/10.1007/978-981-99-5459-9_16</mixed-citation>
     <mixed-citation xml:lang="en">Satya R, Singh A, Rasane P, Poonia A, Singh J, Kaur S, et al. Recent trends in membrane processing of whey. In: Poonia A, Petkoska AT, editors. Whey valorization: Innovations, technological advancements and sustainable exploitation. Singapore: Springer Nature; 2023. pp. 323–353. https://doi.org/10.1007/978-981-99-5459-9_16</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B28">
    <label>28.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Ryazantseva KA, Agarkova EYu, Fedotova OB. Continuous hydrolysis of milk proteins in membrane reactors of various configurations. Foods and Raw Materials. 2021;9(2):271–281. https://doi.org/10.21603/2308-4057-2021-2-271-281</mixed-citation>
     <mixed-citation xml:lang="en">Ryazantseva KA, Agarkova EYu, Fedotova OB. Continuous hydrolysis of milk proteins in membrane reactors of various configurations. Foods and Raw Materials. 2021;9(2):271–281. https://doi.org/10.21603/2308-4057-2021-2-271-281</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B29">
    <label>29.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Манылов С. В. Исследование влияния денатурированных сывороточных белков на свойства низкокалорийных молочно-белковых продуктов: дис. … канд. техн. Наук: 05.18.04. Кемерово, 2009. 156 с. https://www.elibrary.ru/NQOOBV</mixed-citation>
     <mixed-citation xml:lang="en">Manylov SV. Effect of denatured whey proteins on low-calorie milk-protein products. Cand. Sci. Eng. Diss. Kemerovo, 2009. 156 p. https://www.elibrary.ru/NQOOBV</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B30">
    <label>30.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Ferenc K, Sokal-Dembowska A, Helma K, Jarmakiewicz-Czaja S, Motyka E, et al. Modulation of the gut microbiota by nutrition and its relationship to epigenetics. International Journal of Molecular Sciences. 2024;25(2):1228. https://doi.org/10.3390/ijms25021228</mixed-citation>
     <mixed-citation xml:lang="en">Ferenc K, Sokal-Dembowska A, Helma K, Jarmakiewicz-Czaja S, Motyka E et al. Modulation of the gut microbiota by nutrition and its relationship to epigenetics. International Journal of Molecular Sciences. 2024;25(2):1228. https://doi.org/10.3390/ijms25021228</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B31">
    <label>31.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Oztop MH, McCarthy KL, McCarthy MJ, Rosenberg M. Monitoring the effects of divalent ions (Mn+2 and Ca+2) in heat-set whey protein gels. LWT – Food Science and Technology. 2014;56(1):93–100. https://doi.org/10.1016/j.lwt.2013.10.043</mixed-citation>
     <mixed-citation xml:lang="en">Oztop MH, McCarthy KL, McCarthy MJ, Rosenberg M. Monitoring the effects of divalent ions (Mn+2 and Ca+2) in heat-set whey protein gels. LWT – Food Science and Technology. 2014;56(1):93–100. https://doi.org/10.1016/j.lwt.2013.10.043</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B32">
    <label>32.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Хлыстов И. А., Штин Т. Н., Гурвич В. Б., Кузьмина Е. А., Бугаева А. В. и др. Комплексообразующая способность органических соединений и их влияние на организм человека (обзор). Гигиена и санитария. 2020. Т. 99 № 12. С. 1365–1369. https://doi.org/10.47470/0016-9900-2020-99-12-1365-1369</mixed-citation>
     <mixed-citation xml:lang="en">Hlystov IA, Shtin TN, Gurvich VB, Kuz´mina EA, Bugayeva AV, et all. Complexing ability of organic compounds and their influence on the human body (review). Hygiene and Sanitation. 2020;99(12):1365–1369. (In Russ.) https://doi.org/10.47470/0016-9900-2020-99-12-1365-1369</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B33">
    <label>33.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Викторова Е. П., Лисовая Е. В., Свердличенко А. В., Воробьева О. В. Актуальные вопросы применения комплексов микронутриентов для обогащения продуктов питания. Технологии пищевой и перерабатывающей промышленности АПК – продукты здорового питания. 2021. № 1. С. 89–97. https://doi.org/10.24412/2311-6447-2021-1-89-97</mixed-citation>
     <mixed-citation xml:lang="en">Viktorova EP, Lisovaya EV, Sverdlichenko AV, Vorobyova OV. Topical issues of using micronutrient complexes for food fortification. Technologies for the food and processing industry of AIC – Healthy food. 2021;(1):89–97. (In Russ.) https://doi.org/10.24412/2311-6447-2021-1-89-97</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B34">
    <label>34.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Громов Д. А., Борисова А. В., Бахарев В. В. Пищевые аллергены и способы получения гипоаллергенных пищевых продуктов. Техника и технология пищевых производств. 2021. Т. 51 № 2. С. 232–247. https://doi.org/10.21603/2074-9414-2021-2-232-247</mixed-citation>
     <mixed-citation xml:lang="en">Gromov DA, Borisova AV, Bakharev VV. Food allergens and methods for producing hypoallergenic foods. Food Processing: Techniques and Technology. 2021;51(2):232–247. (In Russ.) https://doi.org/10.21603/2074-9414-2021-2-232-247</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B35">
    <label>35.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Щёкотова А. В., Атласова Д. В. Изучение биологических взаимоотношений и биохимических свойств пробиотических микроорганизмов. Вестник ВСГУТУ. 2022. № 3. С. 36–45. https://doi.org/10.53980/24131997_2022_3_36</mixed-citation>
     <mixed-citation xml:lang="en">Shchekotova AV, Atlasova DV. Study of biological relationships and biochemical properties of probiotic microorganisms. ESSUTM Bulletin. 2022;(3):36–45. (In Russ.) https://doi.org/10.53980/24131997_2022_3_36</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B36">
    <label>36.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Грабеклис В. В., Делюкина О. В., Савко С. А. Взаимодействие эссенциальных элементов и кишечной микробиоты: обзор литературы. Микроэлементы в медицине. 2023. Т. 24. № 3. С. 12–21.  https://doi.org/10.19112/2413-6174-2023-24-3-12-21</mixed-citation>
     <mixed-citation xml:lang="en">Grabeklis VV, Delyukina OV, Savko SA. Interaction of essential elements and gut microbiota: A literature review. Trace elements in medicine. 2023;24(3):12-21. (In Russ.) https://doi.org/10.19112/2413-6174-2023-24-3-12-21</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B37">
    <label>37.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Bermúdez-Humarán LG, Chassaing B, Langella P. Exploring the interaction and impact of probiotic and commensal bacteria on vitamins, minerals and short chain fatty acids metabolism. Microbial Cell Factories. 2024;23(1):172. https://doi.org/10.1186/s12934-024-02449-3</mixed-citation>
     <mixed-citation xml:lang="en">Bermúdez-Humarán LG, Chassaing B, Langella P. Exploring the interaction and impact of probiotic and commensal bacteria on vitamins, minerals and short chain fatty acids metabolism. Microbial Cell Factories. 2024;23(1):172. https://doi.org/10.1186/s12934-024-02449-3</mixed-citation>
    </citation-alternatives>
   </ref>
  </ref-list>
 </back>
</article>
