The purpose of the article is to consider a synergetic approach to the formation of an economic space using the example of the Kemerovo Region – Kuzbass. Two agglomerations have been formed in the region, which have their own specialization with centers in the cities of Kemerovo and Novokuznetsk. The authors have revealed that Kuzbass is characterized by demographic compression, manifested in the outflow of population, and communicative compression, the positive effect of which makes it possible to strengthen the transport connectivity of space. An assessment of the transport connectivity of the space is given. The compactness of the territory and the availability of transport communications make it possible to connect municipalities with the centers of agglomerations. Agglomeration economics as a part of spatial economics studies agglomeration (synergetic) effects. To assess the agglomeration effect, labor productivity calculations were carried out in the context of the North Kuzbass and South Kuzbass agglomerations. The author used statistical data from the Territorial Body of the Federal State Statistics Service for the Kemerovo Region – Kuzbass for all municipalities, data from the websites of municipalities, statistics from the Ministry of Economic Development of Kuzbass and transport organizations. The legislative acts of the Kemerovo Region – Kuzbass and the Ministry of Economic Development of the Russian Federation formed the regulatory framework. It has been established that agglomeration effects are more related not to scale, but to the specialization of agglomerations; labor productivity is not always higher in the centers of agglomerations, since its have developed innovative activities (financial, scientific, educational, cultural and educational), which are sources of synergetic effect. It has been revealed that the manifestation of the synergetic approach in the formation of an economic environment space consists in the formation of new growth points in a resource-rich single-industry region that are not related to the leading industry: priority of development territories in four cities (Novokuznetsk, Prokopyevsk, Anzhero-Sudzhensk, Yurga), the Kuzbass special economic zone and the Sheregesh sports and tourism complex.