Foods and Raw Materials Foods and Raw Materials Foods and Raw Materials 2308-4057 2310-9599 92525 10.21603/2308-4057-2026-1-653 Review Article Review Article Review Article Biological value of berry polyphenols and prospects for supercritical extraction application for their isolation: A review Biological value of berry polyphenols and prospects for supercritical extraction application for their isolation: A review https://orcid.org/0000-0002-6835-4513 Guseva Elena V. Guseva Elena V. guseva.e.v@muctr.ru https://orcid.org/0000-0001-9852-9401 Khromova Natalya Yu. Khromova Natalya Yu. https://orcid.org/0000-0002-0976-9700 Karetkin Boris A. Karetkin Boris A. karetkin.b.a@muctr.ru https://orcid.org/0000-0001-8388-4806 Artemiev Artem I. Artemiev Artem I. https://orcid.org/0000-0002-3299-6397 Demkin Kirill M. Demkin Kirill M. https://orcid.org/0000-0002-7776-2922 Puzankova Julia M. Puzankova Julia M. https://orcid.org/0000-0002-1787-5773 Shakir Irina V. Shakir Irina V. https://orcid.org/0000-0002-8158-7012 Panfilov Victor I. Panfilov Victor I. Dmitry Mendeleev University of Chemical Technology of Russia Moscow Россия Dmitry Mendeleev University of Chemical Technology of Russia Moscow Russian Federation Dmitry Mendeleev University of Chemical Technology of Russia Moscow Россия Dmitry Mendeleev University of Chemical Technology of Russia Moscow Russian Federation Dmitry Mendeleev University of Chemical Technology of Russia Moscow Россия Dmitry Mendeleev University of Chemical Technology of Russia Moscow Russian Federation Dmitry Mendeleev University of Chemical Technology of Russia Moscow Россия Dmitry Mendeleev University of Chemical Technology of Russia Moscow Russian Federation Dmitry Mendeleev University of Chemical Technology of Russia Moscow Россия Dmitry Mendeleev University of Chemical Technology of Russia Moscow Russian Federation Dmitry Mendeleev University of Chemical Technology of Russia Moscow Россия Dmitry Mendeleev University of Chemical Technology of Russia Moscow Russian Federation Dmitry Mendeleev University of Chemical Technology of Russia Moscow Россия Dmitry Mendeleev University of Chemical Technology of Russia Moscow Russian Federation Dmitry Mendeleev University of Chemical Technology of Russia Moscow Россия Dmitry Mendeleev University of Chemical Technology of Russia Moscow Russian Federation 25 12 2024 25 12 2024 14 1 1 13 10 07 2024 03 09 2024 https://jfrm.ru/en/issues/23173/23169/

Plant polyphenols are known for their numerous health-promoting properties. This article reviews the current state of research in two related fields, namely beneficial effects of flavonoids for human health, e.g., gut microbiome, and supercritical fluid extraction applied to flavonoids of plant origin. The review covered research articles registered in eLIBRARY.RU, PubMed, and Science Direct in 2005–2025. Polyphenolic compounds obtained from various berries were reported to have a positive impact on gut microbiota, e.g., they stimulated the growth of lactobacilli, bifidobacteria, and other beneficial microorganisms, as well as improved the adhesion of probiotic and pathogenic microbes to intestinal epithelial cells. The review revealed some promising application areas for berry extracts in the functional food industry. Polyphenols can be part of meat formulations due to their strong antioxidant activity. Their antimicrobial effect against a wide range of contaminants renders them good prospects in protecting food products from microbial spoilage. Supercritical extraction is a promising method that isolates biologically active substances from plant materials. The review summarizes its advantages and limitations, as well as the range of prospective co-solvents. Ultrasonication, pulse electric field, and enzymic pretreatment make supercritical extraction more efficient. In general, this extraction method proved to be an excellent means of isolating flavonoids and related compounds from various plants and their parts.

Plant polyphenols are known for their numerous health-promoting properties. This article reviews the current state of research in two related fields, namely beneficial effects of flavonoids for human health, e.g., gut microbiome, and supercritical fluid extraction applied to flavonoids of plant origin. The review covered research articles registered in eLIBRARY.RU, PubMed, and Science Direct in 2005–2025. Polyphenolic compounds obtained from various berries were reported to have a positive impact on gut microbiota, e.g., they stimulated the growth of lactobacilli, bifidobacteria, and other beneficial microorganisms, as well as improved the adhesion of probiotic and pathogenic microbes to intestinal epithelial cells. The review revealed some promising application areas for berry extracts in the functional food industry. Polyphenols can be part of meat formulations due to their strong antioxidant activity. Their antimicrobial effect against a wide range of contaminants renders them good prospects in protecting food products from microbial spoilage. Supercritical extraction is a promising method that isolates biologically active substances from plant materials. The review summarizes its advantages and limitations, as well as the range of prospective co-solvents. Ultrasonication, pulse electric field, and enzymic pretreatment make supercritical extraction more efficient. In general, this extraction method proved to be an excellent means of isolating flavonoids and related compounds from various plants and their parts.

 Plant materials flavonoids prebiotics biological activity intestinal microbiota extraction green technologies supercritical fluid Plant materials flavonoids prebiotics biological activity intestinal microbiota extraction green technologies supercritical fluid The research was supported by the Russian Science Foundation, grant no. 24-19-00298, https://rscf.ru/project/24-19-00298/ The research was supported by the Russian Science Foundation, grant no. 24-19-00298, https://rscf.ru/project/24-19-00298/

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