Foods and Raw Materials Foods and Raw Materials Foods and Raw Materials 2308-4057 2310-9599 83194 10.21603/2308-4057-2025-1-633 Research Article Research Article Research Article Quercetin isolated from Hedysarum neglectum Ledeb. as a preventer of metabolic diseases Quercetin isolated from Hedysarum neglectum Ledeb. as a preventer of metabolic diseases https://orcid.org/0000-0002-4552-7418 Vesnina Anna D. Vesnina Anna D. koledockop1@mail.ru https://orcid.org/0000-0002-3536-562X Milentyeva Irina S. Milentyeva Irina S. https://orcid.org/0000-0002-9546-6633 Le Violeta M. Le Violeta M. https://orcid.org/0000-0002-8071-4411 Fedorova Anastasiya M. Fedorova Anastasiya M. anastasija.fedorova-af2014@yandex.ru https://orcid.org/0000-0001-7035-673X Altshuler Olga G. Altshuler Olga G. https://orcid.org/0000-0002-5630-3196 Prosekov Alexander Yu. Prosekov Alexander Yu. aprosekov@rambler.ru

доктор технических наук;

doctor of technical sciences;

 Kemerovo State University Kemerovo Россия Kemerovo State University Kemerovo Russian Federation Kemerovo State University Kemerovo Россия Kemerovo State University Kemerovo Russian Federation Kemerovo State University Kemerovo Россия Kemerovo State University Kemerovo Russian Federation Kemerovo State University Kemerovo Россия Kemerovo State University Kemerovo Russian Federation Kemerovo State University Kemerovo Россия Kemerovo State University Kemerovo Russian Federation Kemerovo State University Кемерово Россия Kemerovo State University Kemerovo Russian Federation 07 11 2024 07 11 2024 13 1 192 201 05 02 2024 07 05 2024 https://jfrm.ru/en/issues/22431/22634/

Diseases associated with metabolic disorders seem to affect more and more people worldwide. Biologically active supplements may prevent or relieve metabolic disorders. Quercetin is known for its potential to inhibit metabolic syndrome. This paper introduces an in vivo experiment on rodents. It featured hypoglycemic, hypocholesterolemic, and hepatotoxic properties of quercetin. Quercetin was obtained from the hairy root extract of Hedysarum neglectum Ledeb. Two doses (50 and 100 mg/kg) were used to evaluate its hypoglycemic potential. Rats with induced diabetes were tested for body weight, glucose, and cholesterol while mice with induced hypercholesterolemia were checked for blood cholesterol changes. Potential biochemical and pathological changes in the liver were also studied on rats. Quercetin treatment caused neither significant health problems nor death in the model animals. It had no effect on body weight, even in the animals with induced diabetes. In addition, quercetin did not increase glucose and cholesterol in the blood and triggered no pathological changes in the liver. Quercetin isolated from H. neglectum hairy root extract demonstrated no hepatotoxicity. Unfortunately, it showed no beneficial effect on cholesterol and glucose levels and had no efficacy against metabolic syndrome. Further research is needed to assess the effect of quercetin on other metabolic markers, e.g., genes associated with the metabolism of lipids, carbohydrates, etc.

Diseases associated with metabolic disorders seem to affect more and more people worldwide. Biologically active supplements may prevent or relieve metabolic disorders. Quercetin is known for its potential to inhibit metabolic syndrome. This paper introduces an in vivo experiment on rodents. It featured hypoglycemic, hypocholesterolemic, and hepatotoxic properties of quercetin. Quercetin was obtained from the hairy root extract of Hedysarum neglectum Ledeb. Two doses (50 and 100 mg/kg) were used to evaluate its hypoglycemic potential. Rats with induced diabetes were tested for body weight, glucose, and cholesterol while mice with induced hypercholesterolemia were checked for blood cholesterol changes. Potential biochemical and pathological changes in the liver were also studied on rats. Quercetin treatment caused neither significant health problems nor death in the model animals. It had no effect on body weight, even in the animals with induced diabetes. In addition, quercetin did not increase glucose and cholesterol in the blood and triggered no pathological changes in the liver. Quercetin isolated from H. neglectum hairy root extract demonstrated no hepatotoxicity. Unfortunately, it showed no beneficial effect on cholesterol and glucose levels and had no efficacy against metabolic syndrome. Further research is needed to assess the effect of quercetin on other metabolic markers, e.g., genes associated with the metabolism of lipids, carbohydrates, etc.

 Quercetin in vivo Hedysarum neglectum metabolic syndrome hepatotoxicity hypercholesterolemic activity hypoglycemic activity Quercetin in vivo Hedysarum neglectum metabolic syndrome hepatotoxicity hypercholesterolemic activity hypoglycemic activity The research was part of State assignement No. FZSR-2024-0008: Development of biologically active additives consisting of metabolites of plant objects in vitro to protect the population from premature aging. The research was part of State assignement No. FZSR-2024-0008: Development of biologically active additives consisting of metabolites of plant objects in vitro to protect the population from premature aging.

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