Foods and Raw Materials Foods and Raw Materials Foods and Raw Materials 2308-4057 2310-9599 76131 10.21603/2308-4057-2025-1-619 Research Article Research Article Research Article Acid curd (Karish) cheese supplemented with ashwagandha and/or probiotics: Modulatory efficiency on induced behavioral and neurochemical changes in rats Acid curd (Karish) cheese supplemented with ashwagandha and/or probiotics: Modulatory efficiency on induced behavioral and neurochemical changes in rats https://orcid.org/0000-0002-2978-6292 Salama Heba H. Salama Heba H. https://orcid.org/0000-0002-1154-1959 Abdel-Wahhab Khaled G. Abdel-Wahhab Khaled G. https://orcid.org/0000-0001-6008-2157 Khalil Heba M. A. Khalil Heba M. A. https://orcid.org/0000-0003-4420-2731 Abdelhamid Samy M. Abdelhamid Samy M. https://orcid.org/0000-0002-7851-8809 Hassan Laila K. Hassan Laila K. lailakhaled1@yahoo.com National Research Centre Giza Египет National Research Centre Giza Egypt National Research Centre Giza Египет National Research Centre Giza Egypt National Research Centre Giza Египет National Research Centre Giza Egypt National Research Centre Giza Египет National Research Centre Giza Egypt National Research Centre Giza Египет National Research Centre g Egypt 07 11 2024 07 11 2024 13 1 1 17 10 05 2023 10 10 2023 https://jfrm.ru/en/issues/22431/22432/

Neurodegenerative disorder leads to a progressive memory loss that has only limited known medications. The use of ashwagandha, probiotics, or their combination may improve cholinergic activity, consequently providing therapeutic potency against amnesia and neuroplasticity disorders. We aimed to explore the modulatory benefits of ashwagandha extract and probiotics against induced behavioral and neurochemical retardations. Acid curd (Karish) cheese samples were supplemented with ashwagandha extract and/or probiotics and subjected to chemical, microbiological, rheological, sensorial, and biological investigations by standard techniques. The supplementation of Karish cheese with ashwagandha never deteriorated its chemical composition or rheological parameters. On the contrary, it exerted high antioxidant and phenolic potentials. Also, ashwagandha extract performed antimicrobial action against the tested pathogenic bacteria and showed better prebiotic effects with Lactobacillus plantarum. The biological study revealed that treating dementia-modeled rats with Karish cheese supplemented with ashwagandha and/or probiotics resulted in a detectable improvement in the behavioral and neurochemical measurements. However, the cheese supplemented with a formula of ashwagandha and probiotics had the greatest regenerating effect. The supplementation of Karish cheese with ashwagandha and/or probiotics exhibited a modulatory efficiency against experimentally induced behavioral and neurochemical disorders.

Neurodegenerative disorder leads to a progressive memory loss that has only limited known medications. The use of ashwagandha, probiotics, or their combination may improve cholinergic activity, consequently providing therapeutic potency against amnesia and neuroplasticity disorders. We aimed to explore the modulatory benefits of ashwagandha extract and probiotics against induced behavioral and neurochemical retardations. Acid curd (Karish) cheese samples were supplemented with ashwagandha extract and/or probiotics and subjected to chemical, microbiological, rheological, sensorial, and biological investigations by standard techniques. The supplementation of Karish cheese with ashwagandha never deteriorated its chemical composition or rheological parameters. On the contrary, it exerted high antioxidant and phenolic potentials. Also, ashwagandha extract performed antimicrobial action against the tested pathogenic bacteria and showed better prebiotic effects with Lactobacillus plantarum. The biological study revealed that treating dementia-modeled rats with Karish cheese supplemented with ashwagandha and/or probiotics resulted in a detectable improvement in the behavioral and neurochemical measurements. However, the cheese supplemented with a formula of ashwagandha and probiotics had the greatest regenerating effect. The supplementation of Karish cheese with ashwagandha and/or probiotics exhibited a modulatory efficiency against experimentally induced behavioral and neurochemical disorders.

 Ashwagandha Karish cheese Lactobacillus plantarum probiotic therapeutic effect dementia rats Ashwagandha Karish cheese Lactobacillus plantarum probiotic therapeutic effect dementia rats

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